It has not been cleared or approved by the US Food and Drug Administration. 27(3-4):342-351 Synonyms: Undecafluorohexanoic acid, Perfluorohexanoic acid, Perfluorocaproic acid. Chemsrc provides Perfluoroheptanoic acid(CAS#:375-85-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Legacy PFAS have therefore been replaced with shorter carbon chain and polyfluoroether compounds like GenX, 4,8-dioxa-3H-perfluorononanoate (ADONA), perfluorohexanoic acid (PFHxA), and potassium perfluorohexane-1-sulfonate (PFHxS). Recently identified studies conducted with 6:2 FTOH and its metabolite, 5:3 acid, have provided information that enables comparison of the toxicological profiles of PFHxA and 6:2 FTOH. Perfluoroheptanoic acid was detected at 0.007 ng/mL in pooled human milk samples collected 2003 to 2004 from women in the Kingston, Ontario, Canada region (9). Substances targeted in the restriction 23.04.2020 Q & A - online information session • Shall not be manufactured, used or placed on the market as substances on their own; Citation: U.S. EPA. Retention Index (Kovats): 175 (estimated with error: 89) NIST Spectra mainlib_231756, replib_17233, replib_375977. Perfluorohexanoic Acid is a perfluorinated compound (FPC) that can cause acute toxicity to humans and the environment. You’ll find it in products that resist sticking, heat, water, stains, and grease. Some published risk assessments have assumed that perfluorohexanoic acid (PFHxA), a metabolite of 6:2 FTOH, adequately models the human health effects of 6:2 FTOH. The freezing point for perfluorohexanoic acid was determined to be between (291.15 and 293.15) K. The vapor pressures, which ranged from (0.87 to 978) Pa, were used to generate saturated vapor streams of the compound so that adsorption capacities on BPL … PRODUCT AND COMPANY IDENTIFICATION 1.1 Product identifiers The group "perfluoroalkyl and polyfluoroalkyl substances (PFASs)" includes perfluorochemicals (PFCs). Perfluorochemicals (PFCs) are a group of chemicals used to make fluoropolymer coatings and products that resist heat, oil, stains, grease, and water. perfluorohexanoic acid: ChEBI ID CHEBI:83492: Definition A monocarboxylic acid that is perfluorinated hexanoic acid. Perfluoroheptanoic acid. Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon perfluoroalkyl acid (PFAA) and is a primary impurity, degradant, and metabolite associated with the short-chain fluorotelomer-based chemistry used globally today. Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration. PFAS are synthetic chemical substances with special properties and hundreds of manufacturing and industrial applications. Acid PFOS 0.000014 14 4/15/21 375-73-5 Perfluorobutanesulfonic Acid PFBS *0.0021 *2,100 *4/15/21 335-67-1 Perfluorooctanoic Acid PFOA 0.000002 2 1/28/21 355-46-4 Perfluorohexanesulfonic Acid PFHxS 0.00014 140 1/28/21 307-24-4 Perfluorohexanoic Acid PFHxA 0.56 560,000 1/28/21 *Updated health advisory guidance level Compliance Statement. Supplier Information Molecular Weight: … Retention Index (Linear): Perfluorohexanoic acid** PFHxA 0.33 0.009 0.004 Perfluoroheptanoic acid** PFHpA 0.12 0.005 0.003 * PFCs tested in blood by CDC lab, but not tested in water ** PFCs not tested in blood by CDC lab, but tested in water W& > À o ]v Pl> ND = Not Detected . Perfluorohexanoic acid. Perfluorohexanoic acid (PFHxA), a 6-carbon perfluoroalkyl (C6; CAS # 307-24-4), has been proposed as a replacement for the commonly used 8-carbon perfluoroalkyls: perfluorooctanoic acid and perfluorooctane sulfonate. Illinois EPA Issues Health Advisory for Perfluorononanoic Acid (PFNA) SPRINGFIELD – Illinois Environmental Protection Agency Director John J. Kim today announced the issuance of a health advisory for Perfluorononanoic Acid (PFNA) in accordance with Illinois groundwater regulations. 0.2 mL. CHEMICAL AND PHYSICAL INFORMATION 4.1 CHEMICAL IDENTITY Information regarding the chemical identity of perfluoroalkyls is located in Table 4-1. (Reproductive Toxicology, 2009) Gas Chromatography. PFOS and PFOA have been extensively produced and studied in the United States. Perfluorohexanoic acid, Perfluorohexanoic acid supplier, Perfluorohexanoic acid distributor, CAS 307-24-4, Perfluorohexanoic acid manufacturer, Perfluorohexanoic acid wholesale Monoisotopic mass 313.980103 Da. It has been used in the process of making Teflon and similar chemicals (known as fluorotelomers), although it is burned off during the process and is not present in significant amounts in the final products. Under long UV wavelength (365 nm), both tetrapod and commercial ZnO can photodegrade 5:3 FTCA. EPA has investigated PFOA because it: O. The seven PFAS that were detected are: Perfluorobutane sulfonate (PFBS), Perfluoroheptanoic acid (PFHpA), Perfluorohexane sulfonate (PFHxS), Perfluorohexanoic acid (PFHxA), Perfluorononanoic acid (PFNA), Perfluorooctane sulfonate (PFOS), and Perfluorooctanoic acid (PFOA). 2014) and air compartment (Kongpran et al. trcsolutions.com 10 Summary of PFAS Families PFAS Non-polymer Polymer Potential Precursors Perfluorinated Polyfluorinated Precursors PFAAs PFCAs PFSAs FASAs FTSAs FTCAs FTOHs FASEs FASAAs. What is a GreenScreen Assessment? The short chain fluorinated polymers have been used in coatings as materials with low surface energy. Articles of Perfluorohexanoic acid … Elimination kinetics of perfluorohexanoic acid in humans and comparison with mouse, rat and monkey (Chemosphere, 2013) A 90-day repeated dose oral (gavage) toxicity study of perfluorohexanoic acid (PFHxA) in rats (with functional observational battery and motor activity determinations). Requested Volume. Molecular Formula C. 6. Perfluoroheptanoic Acid (as the linear isomer) [LC-MS/MS]: Perfluorohexanoic Acid (PFPxA); Perfluoropentanoic Acid (PFPeA) Perfluorononanoic Acid (as the linear isomer) [LC-MS/MS]: Perfluorodecanoic Acid (PFDA) Turnaround Time. Xenobiotica. Perfluorohexanoic acid is used in stain- and grease-proof coatings on furniture, carpet, and food packaging. Reprod Toxicol. Perfluorooctanoic acid (PFOA) has been a manufactured perfluorochemical and a byproduct in producing fluoropolymers. Perfluorooctanoic acid. PFOA is used as a surfactant because it can lower the surface tension of water more than hydrocarbon surfactants while having exceptional stability due to having perfluoroalkyl tail group. The stability of PFOA is desired industrially but is a cause of concern environmentally. PFHxA Perfluorohexanoic acid C6 PFHxS Perfluorohexanesulfonic acid C6. The other involved a short-chain compound, perfluorohexanoic acid, and long-chain perfluorooctanoic acid, perfluorononanoic acid, and perfluorodecanoic acid. These additives are degraded into perfluorohexanoic acid (PFHxA) which has a rapid bio-elimination rate [76, 127 ]. Illinois EPA Issues Health Advisory for Perfluorononanoic Acid (PFNA) SPRINGFIELD – Illinois Environmental Protection Agency Director John J. Kim today announced the issuance of a health advisory for Perfluorononanoic Acid (PFNA) in accordance with Illinois groundwater regulations. Perfluorooctanoic acid (PFOA) (conjugate base perfluorooctanoate) — also known colloquially as C8 — is a perfluorinated carboxylic acid produced and used worldwide as an industrial surfactant in chemical processes and as a material feedstock. Because peracetic acid solutions contain both peracetic acid and hydrogen peroxide, the measured aquatic toxicities for PAA11 contain contributions from both PAA and hydrogen peroxide. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. •Perfluorohexanoic acid (PFHxA) •Perfluoroheptanonic acid (PFHpA) •Perfluorononanoic acid (PFNA) •Perfluorodecanoic acid (PFDA) •Perfluoroundecanoic acid (PFUnA) •Perfluordodecanoic acid (PFDoA) 7 •Perfluorobutane sulfonic acid (PFBS) •Perfluoropentane sulfonic acid (PFPeS) PFHxA (perfluorohexanoic acid) is a regulated analyte in Michigan with with an MCL = 400,000 ppt; PFHxS (perfluorohexane sulfonic acid) is a regulated analyte in Michigan with with an MCL = 51 ppt; PFNA (perfluorononanoic acid) is a regulated analyte in Michigan with an MCL = 6 ppt Perfluorohexanoic acid (PFHxA, perfluorocaproic acid, undecafluorohexanoic acid, undecafluoro-1-hexanoic Acid) is a six-carbon compound in the perfluoroalkyl family of chemicals. Product Name： Perfluorohexanoic acid CAS ： 307-24-4 Tel： +86-794-7183888 5269166 5269970 Email： sales@groupchem.com Stars This entity has been manually annotated by the ChEBI Team. Buy online at LGC Standards. Perfluorohexanoic acid. 2019 Nov. DOI: 10.1080/00498254.2019.168376. Other PFCs include perfluorohexane sulfonic acid (PFHxS), which is a member of the same chemical category as PFOS; and perfluorononanoic acid (PFNA), which is a … The degradation of perfluorohexanoic acid is complex, due to the stability of the carbon-fluorine (C-F) bond. The hazard levels for each human or environmental health endpoint are assigned by … Fluoropharm, CAS 307-24-4, Perfluorohexanoic acid,OF16068, MFCD00198040, 307-24-4 | Perfluorohexanoic acid,MSDS. The replacement PFAS GenX was recently discovered in NC drinking water sources; … Synergistic or Antagonistic Effects It was also observed that exposure of JEG-3 cells to a mixture of the Retention Index (Linear): Blood. ChEBI CHEBI:38397. Perfluorohexanoic acid PFHxA: Perfluorooctanoic acid PFOA: Perfluorooctane sulfonate PFOS: Perfluorononanoic acid PFNA: Perfluorodecanoic acid PFDA: 8+2 Fluorotelomer alcohol 8:2 FTOH: PFOA, also known as C8, has 8 carbons. 2011; González-Gaya et al. of a single substance was 3,340 ng/g PFHxA (perfluorohexanoic acid) found in a foundation, while the highest concentration of total PFAS (10,700 ng/g) was found in a concealer. perfluorohexanoic acid: ChEBI ID CHEBI:83492: Definition A monocarboxylic acid that is perfluorinated hexanoic acid. 1 mL. ntp technical report on the toxicity studies of perfluoroalkyl carboxylates (perfluorohexanoic acid, perfluorooctanoic acid, perfluorononanoic acid, and perfluorodecanoic acid) administered by gavage to sprague dawley (hsd:sprague dawley sd) rats ntp tox 97 . Catalogue Number PC3454 Synonym(s): Undecafluorohexanoic acid. Perfluorohexanoic acid is a member of a group of perfluorinated chemicals used in many consumer products. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Specimen Type. Systematic Review Protocol for the Perfluorohexanoic Acid (PFHxA) IRIS Assessment (Preliminary Assessment Materials). For Release – July 27, 2021. Perfluorohexanoic acid (PFHxA), a 6-carbon perfluoroalkyl (C6; CAS # 307-24-4), has been proposed as a replacement for the commonly used 8-carbon perfluoroalkyls: perfluorooctanoic acid and perfluorooctane sulfonate. Perfluorooctanoic acid (PFOA) is a long-chain perfluoroalkyl carboxylic acid (PFCA), a subset of per- and polyfluoroalkyl substances (PFAS), that does not occur naturally in the environment. U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-19/050, 2019. Minimum Volume. Perfluorohexanoic acid. Poly- and perfluorinated alkyl substances (PFAS) are widely distributed, environmentally persistent chemicals associated with a broad range of health outcomes. These proposed MCLs were set based on health-based values (HBVs) established by the MPART Science Advisory Work Group. These chemicals are very long lasting and have spread through the environment. Pubmed Abstract. Key values will be displayed on this tab only after a … Supplier Information Molecular Weight: 314.06 Molecular Formula: C6HF11O2 Additional Metadata. Of the sites with detections, seven PFAS were detected. The transition to short-chain fluorotelomer-based products as a cornerstone in replacement fluorochemistry has raised questions regarding potential human health risks associated … Exposure to per- and poly-fluoroalkyl substances (PFAS) like perfluorooctane sulfonic acid (PFOS) or perfluorooctanoic acid (PFOA) are associated with developmental toxicity, neurotoxicity, and carcinogenesis. 1 PERFLUOROHEXANOIC ACID Safety Data Sheet Prepared: 4/24/2015 Revised: 3/11/2015 Printed: 3/16/2016 1. 307-24-4 . As an example, a VigorOx WW II dose to target 1 ppm of PAA in solution will … Perfluoroheptanoic Acid (as the linear isomer) [LC-MS/MS]: Perfluorohexanoic Acid (PFPxA); Perfluoropentanoic Acid (PFPeA) Perfluorononanoic Acid (as the linear isomer) [LC-MS/MS]: Perfluorodecanoic Acid (PFDA) Turnaround Time. The HBVs were set at amounts that pose little to no health risk for those that drink the water over their lifetime. 2014).Severe contamination is particularly found in waste water … Health advisories are issued when there is detection of a chemical … The site is secure. ChEBI CHEBI:35549. Updated EHS Summary of Perfluorohexanoic acid for the MA TURA Science Advisory Board Meeting - March 29, 2017 metabolites observed after oral dosing in either rodent species 40 (Gannon et al. We use cookies to ensure that we give you the best experience of our website. CAS Number 307-24-4 Commodity Code 2915907090 MDL Number MFCD00198040. Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon perfluoroalkyl acid (PFAA) and is a primary impurity, degradant, and metabolite associated with the short-chain fluorotelomer-based chemistry used globally today. august 2019 : Results for Microbial Analytes are not included. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package Brief Method Summary. Inquiry now! The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Perfluorohexanoic Acid is also used as a reagent in the synthesis of 3,3,4,4,5,5,6,6,7,7,7-Undecafluoro-2-heptanol (U787500). Some published risk assessments have assumed that perfluorohexanoic acid (PFHxA), a metabolite of 6:2 FTOH, adequately models the human health effects of 6:2 FTOH. 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